Blossom was a half-hour comedy television series broadcast from 1991 to 1995 on NBC, Mondays at 8:30pm. The series starred Mayim Bialik as Blossom Russo, a teenage girl living with her father and two brothers. It was created by Don Reo.

The series begins with Blossom's mother having left the family to pursue her own life and career and the family trying to adjust. Blossom's dad Nick (Ted Wass) is a session musician who was frequently between gigs and tours. Her oldest brother Anthony (Michael Stoyanov) is a recovering alcoholic and drug addict. Joey (named Donny in the pilot episode) (Joey Lawrence), the other brother, is a fairly stereotypical "dumb jock", known for the drawn-out delivery of his catch phrase, "whoa".

Blossom's best friend Six LeMeure (Jenna von O_) also plays a significant part in her life. Six, an especially fast talker, was best known for her tendency to ramble at an almost incoherent pace. Blossom also frequently received advice from famous celebrities in fantasy scenes, as Mr. T, Hugh Hefner, Phylicia Rashad (who played Blossom's vision of the ideal mother in the first episode) and Will Smith all made guest appearances during the show's run.